The In-Silico Oracle Strikes Again
Once upon a time in a far away land the princess Natira tried to bust the in-silico Oracle, Proton Magic was by her side. We’ll get to her story later. Now, you’ve all heard of the “in silico” virus. Well this in silico oracle doesn’t stop there. Let’s say you sell drugs and your brave new product with a shiny patent costs $100 a pop but the long runner on the block is now generic costing $3 a pop. You’re in a fix unless, you can pay off maker of the long runner to take it off the market, but if that got out you’d all be in a bigger fix. The oracle though is here to save the day, it can just claim that the long runner is carcinogenic! And that’s exactly what has been done to an antidepressant drug called nortryptiline, on the market with no specific carcinogenic sign since 1971.
This paper, studied many types of drugs to see the carcinogenic potential in silico (by computer analysis-just like the making of Sars-Cov-2), and it just so happens that our long runner was in one of the many classes of drugs studied (a tricyclic in this case) that can combine or be metabolized to a carcinogenic compound called a nitrosamine (in the computer). But this aspect wasn’t studied directly: no toxicology study was done on animals or in humans. And, when people get cancer from Covid shots they can blame it on nitrosamines!
The Oracle speaks:
How the hell do they conclude all this stuff? The in silico Oracle said so…😮
Princess Natira’s fight with the Oracle is still coming, your patience please. Now the company making the long runner says they have info (but “no reference”) that the risk is 1 cancer case in 23,000 if you take 150mg a day over 10 years (!) and sent out a warning letter to all the Drs in the country. WTF do they expect these Drs to do? Naturally they will not prescribe it anymore and once they tell all their patients taking the long runner they’ll all agree to change making some depressed and even suicidal, probably more than our magic number of 1 in 23,000 in the next ten years. But our shiny patent drug will be a block buster and all the Drs. can rest assured they’ve saved the day. On top of this nonsense, remember the hypothetical “data” on the 1 in 23,000 is only for the 150mg dose? Almost nobody takes that dose. What about the usual 50mg or 100mg a day? What if it’s not a linear dose-toxicity relationship and the risk for 100mg a day is 1 in 23,000,000,000? That’d be a bummer for the shiny new drug. But there’s “no data” for the lower doses per the drug co. How convenient.
Even beta blockers are on the list of cancer risky drugs, It’s an old drug-killing party:
Behind the scenes Princess Natira fesses-up to the in silico Oracle:
Princess Natira (head lowered): “Your highness in Silico Oracle, I failed you. I doubted the virus existence for a day.”
In Silico Oracle: “Why did you doubt me my dear?”
Princess Natira (stammering in tears), “I was reading too much Proton Magic News, I…I..read every post and…and..I fell in love with that little proton.”
In Silico Oracle: Inaudible murmur, heavy breathing, and black smoke explodes out of the Oracle….Natira rushes into Proton Magic’s arms…...
To be continued….
Do you see Pentagons, triangles, pyramids, checkered floor, a sacrificial alter, and an all-seeing eye in the oracle room or am I crazy?
Guys, please DON’T write diatribes that antidepressants don’t work anyway or their side-effects. There is truth to those in many patients, but that’s not what this post is about. This is about in-silico oracles and Pharma games. Stay on topic, thanks!
Thanks PM! Gem of a post!